Hereditary Cancers in Trinidad and Tobago

Genetic characterization of hereditary cancers in Trinidad and Tobago


https://pubmed.ncbi.nlm.nih.gov/37002211/

I am conducting research into the genotyping germline mutations to determine hereditary link to solid tumor cancers in Trinidad and Tobago and associating somatic mutations with incidence of disease by demographic. (sex, race, age)

Genotyping individuals in Trinidad and Tobago is to determine hereditary susceptible to cancer is very important because it provides the opportunity to test for a growing number of cancer susceptibility genes in an efficient and cost-effective way. It is now possible to evaluate the entire differential diagnosis for a patient and family with a single laboratory specimen. This decreases the time to a potential diagnosis and reduces testing fatigue for patients, families and providers. It can inform not only for diagnoses but also for treatment and prognosis and impact there surgical outcomes. Diagnostics utilizing molecular methods of diagnostics techniques utilizing them in our demographic are very important because we have a mix ethnicity and we are medically underserved. We lose a lot of patient in the clinics due to not coming back for appointments don’t be informed and mutations causing reoccurrence of cancer. We can advice them by knowing initial diagnoses, can be implemented into the health system in Trinidad and Tobago, what there propensity for survival and reoccurrence would be.  Also there treatment can be personalized for a particular mutation.    

Having persons in my family that are affected with cancer has pushed me to research new ways to detect and treat cancer not replacing chemotherapy and radiation therapy but trying to work along side those methods. Learning new methods for example liquid biopsy is a blood test that detects signs of cancerous tumors, including tumor cells and cancer call DNA. A liquid biopsy can identify those pieces. Liquid biopsies can detect both circulating tumor cells and circulating tumor DNA. Also genotyping persons using Genomic DNA obtained from the submitted sample is enriched for targeted regions using a hybridization-based protocol, and sequenced using Illumina technology.

https://www.news-medical.net/life-sciences/What-are-Liquid-Biopsies.aspx

https://pubmed.ncbi.nlm.nih.gov/37002211/

This article shows that liquid biopsy technique can be utilized in cancer detection. this article is one of many I read to add weight to my research. This is a new area to bring to Trinidad and Tobago.

Trinidad and Tobago 

Over the years the number of patients that are diagnosed is increasing. This is because of a number of factors. The food we eat is the number 1 cause of cancers in this country. The chemicals that are being pump into fruits and vegetables is mutating our genes and causing a multiple of problems. Also in meats, birds for example, growth hormones and other disease resistant chemicals are being injected in these birds and we are consuming it at a terrible price.

The fast food industry is also a contributor to the cancer problem. Persons prefer to buy food rather than cook a lovely meal at home due to a number of factors from long working hours to just not feeling to cook. In a nutshell food on a whole is not what is was 20 years ago from garden to table, it’s now farm, process then to table which is one of the major problems in the world we face today.

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